Mini Pause #41: How Nutrition Can Heal Your Hormones

TL;DR (Too Long; Didn't Read)

Change is a good (and even great) thing when it means you’re open to new research, new understanding, and what we continue to learn about the body. What you need in any area of your life will evolve as you grow, mature, and gain new knowledge. Build a solid foundation that allows you to pivot as your body ages.

WHY

Were your ears ringing this week? I was talking about you, thinking about you, and discussing all the ways we are going to work together.

This week during a meeting with my team, we were talking about the future of Hello Betty, the Bettyverse, and of course, YOU.

We were thinking about what the immediate, midterm, and long-term needs of our Bettys are.

And we stumbled upon nutrition. Someone on social media this week commented that she is aggravated because I have “changed my stance” on carbohydrates and nutrition. And it got me thinking.

Had I changed my opinion? In some cases (like fasting) yes.

But others I have not changed, but simply evolved as my nutritional needs changed over time.

So when someone asks me to exactly describe how I am currently eating / training / recovering, the answer is a bit complicated.

There is what I do now, and there is also the foundation I built so that I can do what I do now.

WHAT

As many of you read in The Betty Body, I used to despise my menstrual cycle. It hurt. I was down for the count three or four weeks every month. I was medicating my pain, hating my body, and feeling like it was a curse to be female.

Looking at my labs back then, I had

  • elevated fasting insulin levels
  • high fasted glucose
  • high estradiol levels relative to my progesterone levels
  • high HbA1c levels (a measure of your blood glucose over the past three months)
  • elevated cholesterol levels (TG, LDL-c, and total) that were higher than what was considered normal
  • elevated hs-CRP (a marker of inflammation)

When I look at my life back then, I had a small group of people who were not real friends, just acquaintances. I was in the wrong marriage. I had young kids and limited support. My hair was falling out. I was anxious. And, if I’m honest, falling out of love with my work. I loved my patients and I loved the private practice, but the volume of paperwork and often incorrect staff hires wore me out.

If you’d told that girl to just eat more protein, don’t be scared of carbs, and just lift heavy weights–I would have fallen flat on my face.

Carbs felt awful in my body, I felt constantly hungry and snacky, and the afternoon energetic slump at 2 p.m. was REAL.

I was still lifting weights during this time, and having an almost identical amount of protein that I do now, but felt none of my hard work showed. My waist-to-hip ratio was not where I wanted it to be, and in my luteal cycle, bloating made it look like I was in my second trimester of pregnancy. My genetics revealed I was very prone to (although never formally diagnosed with) PCOS, as well as being on the spectrum for endometriosis.

So what gives?

The answer lies in the nutritional journey to healing.

HOW

For me (and the thousands of women who have gone through The Estima Diet), I needed to establish insulin sensitivity again.

I needed to go low carb first before I could go higher carb. I needed to mildly restrict protein for a bit (my formal thinking hypothesis here is that with protein restriction, you also get methionine restriction–a topic for another Mini Pause), and I just needed to drop some water weight and bloating.

This was the birth of Phase 1 of the Estima Diet.

Then I started cycling my macros with my menstrual cycle and Phase 2 of The Estima Diet was born.

I followed this style of eating for years. In doing so, I watched all my labs normalize, to the point now where my hsCRP now is undetectable, my glucose and insulin are optimal, and my cholesterol (all markers) are pristine.

As I built this foundation of metabolic health, I was able to easily transition to the type of diet I have now in my 40s. If I had to start over again, that would be the path I would take:

  • Estima Diet Phase 1

  • Estima Diet Phase 2
  • Move into the Maintenance Phase, with higher protein and carbs to suit my training demands

You’ve heard me say this before and I’ll continue to say it: The diet you follow to heal is not the one you will follow forever.

The diet that heals you is the one that sets you up for metabolic health so that you have the option to play with different styles of eating later on. With estimates that 88-92% of North Americans are metabolically unhealthy and meet the criteria for Metabolic Syndrome, it's likely that you might also fall into that category.

I did for years.

NOW

  • If you haven’t already, pick up a copy of The Betty Body and follow the nutrition plan in the book.
  • That program saved me, it saved my patients, and saved the thousands of women who went through the program.
  • Stay tuned in the coming months as we revise The Estima Diet in a whole new way. I can’t say much yet, but I can reveal it is going to be a game-changer in the industry.
  • Along with The Estima Diet relaunch, we are going to debut new programs for those of you who want to go deeper into your health journey and work with me.

If you have gone through The Estima Diet and are ready for more, as well as those of you interested in taking your health in a new direction, reply “ESTIMA DIET” to support@drstephanieestima.com.

We're Making a Q&A Change

You've asked and I've answered 40 questions in this column this year. Thank you to all my Bettys who took the time to write in and ask such great questions!

In September, we began offering full Ask Me Anything episodes in the new EVEN BETTER! Premium Membership. Each month we open up a new AMA to member questions on a specific topic. These Qs form the foundation of a full AMA episode which appears in the members' private podcast feed and on their membership dashboard.

Now that this membership feature is available, we'll be sunsetting the Mini Pause QOTW. To continue to get your questions answered about Meals, Muscle, Mindset and (Peri) Menopause (and more!), I'd love for you to join us in the EVEN BETTER! Premium Membership community.

Membership benefits are outlined for you directly below. You can sign up HERE.

What I Recommend: Sauna

Adding regular sauna sessions into my routine has made a significant difference in my recovery and overall health. The science is clear on sauna benefits. For their 25th Anniversary, Sunlighten is offering up to $600 off PLUS a FREE gift with purchase through Oct. 31. The FREE gift with purchase includes an at-home biomarker panel test and educational webinar.

  • The biomarker panel test covers 17 markers across six categories (Lipid and Cardiovascular Markers, Metabolic Health, Inflammation, Hormonal Health, Thyroid Function, and Nutritional Status).
  • The webinar will be hosted by Dr. Darshan Shah, who will dive deeper into understanding these biomarkers.

Link HERE to more about the Sunlighten sauna models and take advantage of this special promotion.

Now Open: EVEN BETTER! Premium Membership Subscription

Members have immediate access to numerous content pieces, with more coming online. The membership benefits were designed with input and insights from my community of women. Here's what you'll find within the membership:

  • Early and ad-free access to the weekly Better! podcasts.
  • A downloadable action guide for each podcast episode.
  • Private “Ask Me Anything” episodes based on member questions.
  • Surprise guests and solo shows only for members.
  • My insights from the guest discussion coupled with recommendations you can use to build habits and routines that support your goals.
  • Bonus content beyond the podcast episodes.
  • Exclusive discounts for brands I love.
  • Being a part of a community with like-minded Bettys!

Subscribe HERE to find several introductory membership options to fit your budget.

Mini Pause #28: Your Guide to Progesterone in Perimenopause

What to Know & What to Ask Your Healthcare Provider

TL;DR (Too Long; Didn't Read)

Progesterone is often the first hormone replacement women begin taking in perimenopause.

WHY

Progesterone is often the first hormone replacement women take in perimenopause. This is likely due to clinical symptoms like a shortened menstrual cycle, spotting, poor recovery from exercise, sleeplessness, and increasing anxiety or depression that is atypical for you.

Progesterone has several roles as it relates to the menstrual cycle, such as:

  • Decreasing uterine contractions to allow for implantation.
  • Increasing vascularization and blood flow to the uterus.
  • Increasing mucosal thickening in the cervix (to prevent more sperm from getting in, as well as serving an immune function to the woman [*]).

Progesterone has many functions in the body beyond regulating the menstrual cycle, too, like:

  • Bone formation [*] and prevention of osteoporosis.
  • Protection of neurons in both the central and peripheral nervous systems for neurodegenerative diseases.
  • It also interacts in the musculoskeletal system with estrogen to help form peak bone mineral density.

Progesterone is not solely for your uterus. It’s a systemic hormone. If you do not have a uterus, you can still benefit from supplementing with this hormone (although this must be discussed with your primary prescribing healthcare provider!).

WHAT

If you’re noticing your menstrual cycle shortening, or you’re noticing spotting a few days before your actual period begins, these are usually telltale signs that your progesterone levels are dropping. Coupling this with changes in mood, affect, sleep, or general recovery from exercise would certainly warrant a conversation with your provider about whether progesterone therapy is right for you.

HOW

There are several ways progesterone is administered. The two most common ways are oral, micronized progesterone and topical progesterone cream.

Prescribed oral micronized progesterone is called Prometrium and is chemically identical to the progesterone we make in our bodies. It’s available in 100mg or 200mg doses and recommended that you take it at night because it can cause drowsiness and even dizziness. Taking it before bed helps to minimize these common side effects.

A few other side effects to note with Prometrium that are true for some but not all women:

  • Water retention
  • Bloating
  • Increased appetite
  • Mood changes

While these side effects can be temporary when first starting the drug, it’s important to make sure you keep a log of any symptoms you experience to be able to communicate this with your provider.

In terms of dosing: If you’re still cycling, it’s commonly recommended for you to take the progesterone in the second half of your cycle, from the midpoint (usually day 14) to the first day of your period.

If you are menopausal, or you have no idea where you are in your cycle, there are a few schools of thought on progesterone best practices:

  • Take it daily, irrespective of where you are in your cycle.
  • Take it for two weeks, and then break for two weeks, mimicking the natural rhythms of progesterone secretion in the fertile years.

There is no “better” one way, so expect a bit of experimentation and dialogue between you and your primary prescribing healthcare provider.

NOW

  • If you are not already tracking your cycle–start! Even if it’s irregular. You need some foundational data.
  • If you notice changes in the length of your cycle, spotting, or mood and energy changes, it might be worthwhile discussing with your provider what your options are based on your health history.

Question of the Week

Q: As a 45-year-old woman, what are the ideal estrogen/progesterone levels or range to look for?

Gina asks a question that I think is difficult to answer for everybody because it’s only one part of three questions that you must consider. So, I can give you a framework to think about what is optimal for you.

We can look at ratios, but we are looking for 1) both absolute numbers to be optimal, 2) the relative ratios of each to be optimal, and then, 3) symptom management to be on point.

To be direct, you want an estrogen: progesterone ratio to be somewhere between 100 and 500. Anything less than 100 usually indicates that too little progesterone and too much estrogen in the luteal phase of the menstrual cycle.

It’s important to know that you can still experience signs and symptoms of estrogen dominance even if your estrogen and progesterone levels are within the normal range. This is why you and your healthcare provider should always consider ratios, absolute levels, and your menstrual cycle experience.

YOUR TURN!

I’ll be answering your questions every week right here in the Mini Pause! Let me know what’s on your mind. I’ll be checking for both questions and feedback at support@drstephanieestima.com.

What I Recommend: Supplements for Performance, Cellular Health & Aging

In last week’s Mini Pause #27, I laid out my supplement routine to answer your questions about what I take regularly to support my health and fitness goals, feel my best, and age well. I wanted to mention a few others that I rotate in that you may find are a good fit for your own lifestyle.

Essential Amino Acids (EAAs): These building blocks of protein are vital macronutrients for your fitness and overall health. If you’re a fitness professional, a competitive athlete, or regularly train for specific performance goals, the nine essential amino acids are a must. They are crucial to boosting your energy, building lean muscle, and helping your body repair and recover. Learn more about EAAs in this guide that makes the nerdy science easier to understand.

  • Try KION and use DRSTEPHANIE for a discount at checkout.

Fatty Acids: Essential fatty acids create better skin, hair, and nails, repair age-related damage to cells, and activate pathways that regulate sleep and mood. Fatty 15 is a science-backed, patented, and award-winning essential fatty acid formula that helps reverse 36 clinically relevant and aging-associated changes at the cellular level, effectively protecting your cells (and you) against age-related breakdown.

  • Try Fatty 15 and use code DRSTEPHANIE to get 10% off a 90-day subscription Starter Kit

Spermidine: Wholly plant-derived spermidine promotes hormonal balance, energy, and hair growth. It also slows aging on a cellular level by activating cellular renewal, or autophagy, which mimics the benefits of fasting. Spermidine supports sleep quality; memory, cognition, and brain health; skin and nail health–all of which can change during midlife.

Mini Pause #21: How Caloric Deficits Impact Your Bones, Muscles & Tendons

TL;DR (too long, didn't read)

Caloric deficits impact the trajectory of women’s bone density and muscle mass. Caloric deficits also can impact women’s height, ability to build muscle, and menstrual cycle. We must reframe our thinking from being as skinny as possible to being as strong as possible.

WHY

Oh, look! I have more to say about chronic caloric deficits. Hold my beer.

Just kidding. I never drink the stuff. But… I have been thinking about chronic caloric deficits and the impact it has on a woman over her lifetime. Specifically, I want to talk about not getting enough calories in and how seriously it affects your bones, muscles, tendons, and joints, and injury risk.

Last week, I touched on the idea that eating in a caloric deficit can have deleterious effects not only on your gainz, but also on other important areas of female health like menstruation, bone health, brain health, and hormone production.

Let’s tuck into this a bit.

WHAT

One of the things I couldn’t shake after writing last week’s Mini Pause #20 is that most of us have been on some kind of diet for all of our lives. That means that for many women, we have been trying in some form or another to starve ourselves skinny. So at best, we have underestimated our calories thinking we are in a deficit, and at worst, we’ve fostered a real, chronic caloric deficit that impacts organ function and tissue remodeling and maintenance.

I wanted to expand on last week’s newsletter because it has real consequences on our body’s ability to function normally.

Most obviously, chronic caloric restriction is going to affect the regularity and cadence of our menstrual cycle. I write about this extensively in The Betty Body and why women are still getting periods (no matter how irregular they may be).

If your body fat percentage is too low, you run the risk of depriving yourself of ovulation, which is the main point of your menstrual cycle. In doing so, you also deprive your body of progesterone. This sex hormone is only produced when you ovulate.

Progesterone has wide-sweeping effects on the body like promoting good sleep, calming anxiety centers in the brain down, and supporting thyroid function–all three of which perimenopausal women tend to struggle with.

But there are other, perhaps more deleterious effects of prolonged caloric deficits, such as the effects it has on your bones and muscles.

Young women who under-eat and have lost their menstrual cycle as a result of over-dieting are at risk for developing irreversible damage to their skeletal system because 90% of our bone mass peaks at about 18 years of age [*]. This means that without adequate nutrition, a teenager who is undereating will impair her bone strength; change the architecture of the bone itself, causing it to have a higher affinity for bone fractures; and can even change her final height [*]. It puts this young woman at a higher risk of vertebral fractures throughout the rest of her life, even if she resumes normal eating patterns.

Having seen my fair share of vertebral fractures in my clinic, this is something you want to avoid at all costs. It is painful and disruptive, and the rehab is incredibly difficult from both a physical and mental point of view.

Amenorrheic episodes (months without ovulation) also impact your anabolic hormones like estrogen. Without a regular menstrual cycle, you would be considered hypoestrogenic, which is not too dissimilar to what we see in the final stages of perimenopause and menopause.

In both age groups, we see a fraying of the bone architecture, an increased susceptibility to fractures, and reduced bone strength. We want bones that are more “bendable” to withstand the forces on them. The more brittle and less “bendy” a bone is, the more likely it is to snap.

The other deleterious effect chronic caloric deficits have are on our body’s ability to repair and grow new muscle tissue. Muscle is so much more than aesthetic, as you know. Undereating is associated with impaired myofibrillar and sarcoplasmic muscle protein synthesis [*], compared to training with optimum energy availability.

Being on a chronic diet for YEARS is going to measurably impact your muscle mass, bone density, injury risk, and organ health. And it will catch up to you eventually.

HOW

I wish I could snap my fingers and wake us all up from the collective spell of wanting to be skinny, but the truth is, each of us will have our own paths to this awakening. What I can say to the well-intentioned woman (possibly the one reading with a touch of cynicism who gets what I’m saying intellectually but emotionally still desires to be small) is that your worth is not what the scale says.

If you have a lot of muscle mass, you are likely going to be heavier than whatever arbitrary number you have in your head. That number by the way has been subtly implanted from reading Cosmo, Teen Cosmo, and whatever other junk we grew up reading.

Think deeply about the images of thinness growing up. Women in perimenopause know this intimately because if you are around the same age I am, you grew up with Kate Moss and the advent of the grunge and heroin-chic look.

I distinctly remember as a teenager who was studying fashion magazines, that my body was just not built like the girls on these pages. I have thighs that are always going to touch. I have hips made for childbearing. I am just built differently.

Of course, these physical qualities have been in vogue as of late, which also just goes to show you the standards of beauty are always changing. So find the beauty in your own damn self and stop looking for external validation. Love your freckles, your scars, your hair color. Because soon stars will take out their BBLs, strong Roman noses will be the new ideal, and thin eyebrows will be back.

Point is–the house always wins. So be the house. Not the player.

NOW

  • Play India Arie’s “Because I Am a Queen
  • Think about your relationship with food and dieting and what messages your daughters and sons are receiving. Is it good? Bad? Neutral
  • Contrast that with how you would like to show up for yourself, your family, and your community.
  • Can you experiment with eating a little more? What if you started with simply 100 calories more of protein? Could you make that work?

Q: I know I need more calories in my luteal phase. Can I increase fat? Or do I need to add more carbs?

Short and to the point for Divie3 from Instagram today.

Yes, if you are hungrier you definitely need more calories. I usually recommend something like 10 to 15 percent more than you are eating in your follicular phase. The first thing is to make sure your protein intake is adequate. Typically something like 1g of protein/per ideal pound of body weight. After that you can dial up fat or carbs; whatever tickles your fancy!

YOUR TURN!

I’ll be answering your questions every week right here in the Mini Pause! Let me know what’s on your mind. I’ll be checking for both questions and feedback at support@drstephanieestima.com.

What I Recommend: Red Light Therapy

I’ve added another component of light therapy to my recovery practice. (Yes, that's really me lying on it in the photo).

While my Bettys know how much I rely on science when it comes to all things wellness, I’m going to admit that the PEMF Mat by Bon Charge both soothes and energizes in ways I wasn’t expecting–and I loved it right away.

It’s a pulsed electromagnetic field mat that works with your body’s natural magnetic field and uses bioactive wavelengths combined with red and near-infrared light. An additional far-infrared light component warms your body.

You can use the PEMF Mat during yoga, stretching, or grounding while lying down. You can even read a book or take a nap. The Mat’s programming allows you to choose sleep, grounding, focus, or meditation and relaxation.

And ever searching for ways to be more efficient, I combined my Red Light Face Mask and Red Light Neck & Chest Mask with time on the PEMF Mat. It’s a triple win for wellness. Speaking of triple, the PEMF Mat now comes in three sizes: a sitting pad, a demi size, and the full size.

View the entire Red Light Therapy Collection here and use code DRSTEPHANIE to save 15% off sitewide.

How Peptides Combat Collagen Loss

As if we didn’t have enough to deal with managing low energy, mood swings, and brain fog, within the first five years after menopause, we can expect to lose 30% of our skin’s collagen — and collagen production continues to drop another 2% every year for the next two decades!

Even if you aren’t concerned about the aesthetic impact of collagen loss (namely lines, wrinkles, and sagging skin), there’s a health component involved, which I explain in more detail below.

But what triggers these changes? Just like other symptoms common in perimenopause and menopause, it’s due to shifts in estrogen and progesterone.

The Role of Estrogen and Progesterone on Skin

  • Skin Barrier: Estrogen stimulates the production of several key proteins in the skin, keeping your skin barrier healthy and strong. However, as estrogen levels decrease, your skin can become thinner over time [*], which puts you at greater risk for moisture loss, infections, and UV damage.
  • Oil Production: Declining levels of progesterone can lead to skin that’s drier and more sensitive since this hormone is involved in the skin’s oil production.
  • Free Radicals: As estrogen levels drop, the body’s natural defense [*] against free radicals becomes less effective, leading to accelerated skin aging.
  • Hyaluronic Acid: Estrogen also stimulates the production of hyaluronic acid. Without a strong skin barrier and the estrogen-stimulated production of hyaluronic acid, the skin will feel more dehydrated [*].
  • Sun Sensitivity: When estrogen levels decrease, so does melanin, the pigment that helps protect skin from UV rays. This means, you might notice that your skin becomes lighter and that you’re more sensitive to sun damage [*].

How I Keep My Skin Healthy After 40

In addition to eating foods rich in antioxidants, using broad spectrum sunscreen, and getting quality sleep — which can all affect the health of your skin — I recently found a skincare line developed by a team of female scientists.

The company is called OneSkin. And their products, called “topical supplements,” are powered by their proprietary OS-01 peptide which is scientifically proven to counteract some of the factors caused by estrogen decline during menopause.

In lab studies, they found that OS-01 increased collagen and hyaluronic acid production in skin (1), improving firmness, elasticity, and hydration and strengthening the skin barrier (2). Not only that, their peptide is proven to reduce cellular senescence (3), one of the hallmarks of skin aging, so your skin stays younger and healthier as you age

I’ve shared with my Bettys that I’m completely up-leveling my skin this year. I’d love for you to consider how you can do the same. My absolute go-to product from the OneSkin line is OS-01 SHIELD Protect + Repair SPF 30+. This mineral-based sunscreen comes in both tinted and clear. If the science of peptide skin care intrigues you, visit oneskin.co. (Use code DRSTEPHANIE at checkout to save 15%.)

1) Shown in lab studies on human skin samples by measuring collagen production biomarker, COL1A1, and hyaluronic acid production biomarker, HAS2. Treatment with the OS-01 peptide displayed a significant increase compared to no treatment. (Zonari, A., et al. npj Aging, 2023)

2) Shown in a clinical study performed by a third party research organization. Skin barrier and hydration measured by a vapometer. Elasticity and firmness analyzed via double-blind expert clinical grader evaluation. Significant improvements were observed on skin treated with OS-01 FACE for 12 weeks versus baseline. (Zonari, A., et al. Journal of Cosmetic Dermatology, 2024)

3) Shown in lab studies on human skin samples and/or cells by measuring the number of senescent cells via SA-Bgal staining, senescence biomarkers (CDKN2A/P16, CDKN1A, H2A.J), and SASP biomarkers (CXCL8 and IL-6).  Treatment with the OS-01 peptide displayed a significant decrease in all mentioned markers compared to no treatment. (Zonari, A., et al. npj Aging, 2023)

***

Disclaimer: The information included in a newsletter, email, or on drstephanieestima.com is intended solely for educational purposes. It does not replace a direct relationship with your licensed medical provider and is not intended to diagnose, treat, cure, or prevent any disease.

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