Your Mitochondria Called—They’re Ready for a Glow-Up

The Powerhouses That Power Your Midlife

As we navigate the perimenopausal and menopausal journey, our bodies undergo significant changes that can affect our energy, muscle strength, and overall vitality. While hormonal shifts often take center stage in conversations about this transition, there's another crucial factor that deserves our attention: mitochondrial health.

What Are Mitochondria and Why Should You Care?

Mitochondria—often called the “powerhouses of the cell”—generate the energy that fuels everything from our muscle movements to our cognitive function. Think of them as your body's microscopic power plants, converting nutrients into ATP, the energy currency your cells need to perform their functions.

For women in midlife, maintaining robust mitochondrial function becomes increasingly important. Research shows that mitochondrial efficiency naturally declines with age, contributing to the fatigue, muscle weakness, and decreased recovery capacity that many women experience during and after menopause.

The Mitochondria-Menopause Connection

During menopause, declining estrogen levels directly impact mitochondrial performance. Estrogen helps regulate mitochondrial function and provides protection against oxidative stress—when this protection diminishes, our cellular powerhouses become less efficient.

The good news? Emerging research suggests we can actively support mitochondrial health during this transition through specific lifestyle practices and targeted nutrition.

Mitophagy: Your Cellular Renewal System

Our bodies have a natural process called mitophagy that removes damaged mitochondria, making way for healthier, more efficient ones. Think of it as your body's built-in quality control system for energy production.

However, this renewal process slows as we age, allowing damaged mitochondria to accumulate. This accumulation contributes to many hallmarks of aging, including muscle loss (sarcopenia) and decreased energy—challenges that disproportionately affect women in menopause.

Urolithin A: A Breakthrough for Mitochondrial Health

Recent scientific discoveries have identified a compound called Urolithin A that can significantly boost mitophagy. This postbiotic compound helps clear out damaged mitochondria and stimulates the production of new, more efficient ones.

Clinical research shows impressive results: In one study, adults taking Urolithin A experienced up to a 12% increase in muscle strength without changing their exercise routines. Another study demonstrated improved endurance and muscle function after just four months of supplementation.

The Gut-Mitochondria Connection

Interestingly, Urolithin A isn't found directly in foods. Rather, it's produced in our gut when we consume certain foods rich in polyphenols, like pomegranates and berries.

The catch? This conversion depends on our gut microbiome composition, and research indicates most people lack the specific gut bacteria needed to produce therapeutic levels of Urolithin A, regardless of how healthy their diet is.

Supporting Your Mitochondria with Timeline

Timeline Nutrition has developed Mitopure®, a clinically tested, highly pure form of Urolithin A that delivers a precise dose directly to your cells. Unlike relying on dietary sources alone, Mitopure ensures you receive the optimal amount for mitochondrial renewal.

Their product line includes convenient capsules, versatile powders, and their newest offering—delicious gummies that make mitochondrial support feel like a treat rather than a chore. Additionally, Timeline offers complementary supplements and skincare formulated to support cellular health from the inside and out.

Ready to energize your midlife journey? Timeline is offering my Bettys a 10% discount on all products when you visit https://shop.timeline.com/DRSTEPHANIE and use code DRSTEPHANIE.

Experience how mitochondrial support can transform how you feel during this powerful life transition.

Mini Pause #54: 10 Ways to Put Your Health First

I'm switching things up this week to bring you my best resources to help you navigate the year ahead (and well beyond). For those of you new to the Bettyverse, welcome! I'm delighted you're here. And for my longtime followers, thank you for your continued support.

FREE RESOURCES

Mini Pause: If you're reading this, you've already signed up for my Mini Pause newsletter. There are now 54 issues (!) offering information, education, and practical takeaways on topics relevant to midlife, especially perimenopause and menopause.

  • You can browse all the newsletters and blog articles in the catalog here.

BETTER! with Dr. Stephanie: Next week, I'll air the 400th episode of my podcast! It's truly a labor of love to talk with experts and bring you fresh perspectives on meals, muscle, mindset, hormones, and much more. Take a listen!

  • Did you know I offer a Personalized Podcast Playlist? Take a short quiz (only four questions) to get a playlist targeting what's most important to your health.
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PREMIUM MEMBERSHIP

EVEN BETTER! If you already love the podcast, this private community offers exclusive access and perks. You'll get early and ad-free weekly podcasts; candid post-podcast commentary; “She Said, She Said” episodes with Cynthia Thurlow, ND (we spill some tea in these talks!); “Ask Me Anything” episodes (recorded & live); my solo shows, where you get my unfiltered views and recommendations along with tips to help you build habits and routines that support your goals; bonus content; and exclusive discounts on my favorite brands.

  • Check out subscription options here.

YES! YOUNGER, ENERGIZED & STRONGER

New Coaching Program: I'm back to LIVE teaching this year with the debut of an 8-week program designed exclusively for women in perimenopause and menopause. With my focus and formal education in nutrition, exercise physiology, and biomechanics, I'm tailoring the program to suit women within three distinct pillars: Younger targets mitochondrial health and biological aging; Energized targets metabolic health; and Stronger targets female-specific biomechanics and weight-lifting. We'll discuss hormones, nutrition, movement, strength, and mindset. You'll also learn real-life strategies for increasing energy, reducing brain fog, and managing stress.

  • If you missed the first FREE introductory session on Jan. 14, you can watch the replay here and decide if it's for you. Doors are open until Jan. 21, when we'll dive into the course programming. Register here and use code JANUARY to drop the cost to $497.

HEALTH TOOLKIT

Body, Mind & Life: I get asked all the time about the supplements I take, the skincare I use, the tech that helps me train and recover, and overall ways to improve resilience and feel great at this stage of life. I've curated my favorites in an online toolkit for you. These are products I actually use that have helped me build supportive routines. I've partnered with amazing brands to get you discounts on every item. Take a look!

FOLLOW ALONG

  • Instagram: I'd love to see you on my social page. I share workouts, recipes, health tips, excerpts about my life, and much more. It's a bright, fun place to be.
  • Website: My website is information central. It includes all the items I've listed above plus other sections. Last year, we developed special sections for the podcast's 5th-anniversary giveaway and an online holiday gift guide. So, be sure to visit often!

What I Recommend

How Red Light Can Ease Perimenopause & Menopause Symptoms

Perimenopause and menopause can come with some unwelcome changes to how you look and feel. From sleepless nights to thinning hair, dry skin, and even changes in bone health, you could start to feel like your body is no longer your own. But what if an effortless, non-invasive treatment could help you start feeling like yourself again?

Enter red light therapy. Backed by research, this drug-free, largely hands-off practice has shown promise in improving some of the most unnerving symptoms of hormone changes, potentially improving sleep, reducing inflammation, supporting hair growth, promoting bone health, and even rejuvenating skin.

I take you through the reasons I recommend red light to my Bettys in this article.

Mini Pause #53: Fat Loss Basics-Tucking Into Calories & Hunger

Fat Loss Basics: Tucking Into Calories & Hunger

TL;DR (Too Long; Didn't Read)

Fat loss is relatively easy to figure out, and somewhat harder to execute.

In this issue, you’ll figure out your maintenance calories and how much to reduce your calories by in order to target adipose tissue.

And if you don’t want to do it alone, I can help. (Read to the end to see how!)

WHY

The one question I get most often, especially when it pertains to strength, is “How do I do this when my primary goal is to lose fat? I’m totally game for building muscle, but is there a way to do both at the same time?”

The other version of this I get is: “Should I lose the fat I want first and then embark on a muscle-building program?”

There persists a fear around body fat, even for a short period of time, and I hope that these Mini Pause newsletters (that you’re sharing with your friends, right?) help to educate you and shine a light on the beliefs (however correct or incorrect they may be) are driving your behaviors.

I’m a BIG fan of efficiency and momentum. Meaning, that if I’m going to dedicate resources like my attention to something, I want it to work.

Not sort-of work.

Work.

For most of us, we can think about approaching fat loss and muscle building in phases. You can, technically, build muscle in a fat-loss phase but it is orders of magnitude more difficult to do than to approach each goal separately.

If I told you to learn French and Italian at the same time–could you do it? Sure. But over time, you are going to mix up the languages. One language becomes more dominant than the other, making the weaker language more difficult to access.

The same is true for body goals. You can do them at the same time, but it will be slower.

Let’s focus on fat loss. Given that it is still January, I suspect many of you are at least slightly more interested in fat loss right now.

WHAT

So first, let’s state the obvious. Whenever we are talking about weight loss, what we really want to zoom in on is fat loss.

I’m assuming you are not trying to reduce density in your bones, weight or volume of your brain, or your muscles–all, of course, have weight to them.

It is the adipose tissue you want to get under control. Especially the adipose tissue that begins to migrate to your midsection in your 40s.

The first thing to do when embarking on a fat loss journey? Get a sense of what kind of caloric intake you currently have and ask yourself if it’s having a net zero effect on your weight.

You have to determine how many maintenance calories are required to either gain or lose weight.

There are a couple of ways to do this. The first method (1) is longer and more accurate; the second method (2) is faster and less accurate.

  • Keep a food journal for one to two weeks. Literally track every lick, taste, and bite. Include the weekends and the stress eating. Everything. Because if you can see after a week or two that nothing happens to your weight, then you can accurately estimate your maintenance calories.
  • Use an online calculator to estimate how many calories you burn right now, with your current level of activity.

HOW

After you figure out your maintenance calories, you can figure out how to reduce your calories so that you’re coming in with a net calorie deficit. That’s when you start tapping into stored fat as your energy fuel.

This is what fat loss entails. Weeks of a caloric deficit under your maintenance calories.

It’s boring. Sorry, not sorry.

You can start with a certain percentage below your maintenance calories. I honestly like to be gentle here, but research indicates that as long as you’re getting enough protein, you can safely decrease your calories to 25% less than your maintenance calories. I recommend something a little less than 25%, and if needed, you can ramp up.

I’m always a fan of taking a long-term view of fat loss, muscle gain, and managing things like hunger.

And you’re going to be hungry when you’re in a fat loss phase. Expect it.

What percent of a caloric decrease you can tolerate and maintain comes down to a few key things:

Is your nutrition already dialed in?

  • Are you already lifting weights and eating sufficient protein?
  • What’s your current body composition?
  • What’s your current fitness level?
  • Have you engaged in a fat loss phase previously? How successful was it?

NOW

If you have a fat loss goal this year, start here:

  • Figure out your maintenance calories
  • Decide by how much you are going to reduce your caloric intake
  • Expect hunger with slight to moderate discomfort

If you don’t want to do this alone, I’m starting a brand new program on Jan. 14 that addresses this very issue (along with muscle-building).

You’re invited to participate in the first class for FREE.

In this 8-week program, you’ll learn you to figure out your calories, what your caloric deficit should be for you, as well as how to begin to build muscle and implement healthy habits not only for this year but also for life.

This is my first coaching cohort in over two years (!) and I’m so excited to get going again!

➡️ If you’d like to join me and a group of like-minded women, reply YES to support@drstephanieestima.com, and you’ll get all the details!

Say YES! to Feeling Younger, Energized & Stronger

YES is my new eight-week program designed to help you lose fat, gain muscle, and feel your most vibrant. We’ll focus on mitochondrial health, metabolic health, nutrition, biomechanics, and strength training specifically for women.

I'll be leading you through the program during weekly LIVE coaching calls, as well as tools and a community space for you to interact with other women.

To participate, reply to support@drstephanieestima.com with the word YES in the subject line to join the first session for FREE, and I’ll send you all the details.

YES starts with the FREE first session on Tuesday, Jan. 14 at 7 p.m. ET

  • The first class is my gift to you with no obligation to continue.
  • If you'd like to join the first session, but can't make that date and time, let me know in your “YES” response and I'll send you the replay.

What I Recommend

Increase Resilience, Improve Cellular Health & Manage Hormonal Changes

TRY COLD PLUNGING

I've been talking to you about the benefits of cold water immersion therapy for well over a year now. It took me a while to take the plunge (pun intended!), but when I did, I went all in…albeit one extremity at a time! And I don't want you to miss out on the benefits like improved sleep, balanced energy and mood, sharper focus, and reduced stress.

  • My first podcast guest of 2025 was Marie Bodine, a cold performance and mindset who's also a level 2 certified Wim Hof Method instructor and a Spartan athlete. Take a listen to BETTER! episode #398 for a cold water “how-to” guide.
  • Read about how cold water immersion helps ease perimenopause and menopause symptoms in this article.
  • Find out what I recommend for women when it comes to cold plunging: time, temperature, warming up afterward, and more in this newsletter.

➡️ If you're ready to try cold plunging at home, visit Coldture and use code DRSTEPHANIE to save $200. Culture also offers financing, a 30-day risk-free trial, and free shipping,

EMPOWER YOUR CELLS

Wouldn't you like to feel renewed in the New Year? With Timeline’s Mitopure®—a rare postbiotic called Urolithin A—you absolutely can.

Mitopure® (in capsules or powder form) supports your health at its foundation and encourages cellular renewal. It's clinically proven to target the effects of age-related cellular decline.

This means you'll have more energy, better workouts, and faster recovery, and you'll be preserving your health, mobility, and strength as you age.

Mitopure® also empowers your cells to replenish your skin from the inside out, which makes their skincare line so effective I can't do without The Serum morning and night.

➡️ Timeline's New Year's discount is going on now for a limited time. Visit Timeline to get 33% off nutrition and skincare.

BALANCE YOUR HORMONES

Hear from more than 20 women’s health experts–including me!–to get science-backed solutions, practical tools, and daily practices to manage your menopausal journey.

➡️ Click HERE to register for the FREE Menopause Redefined Summit, happening January 21–24, 2025.

EVEN BETTER! Premium Membership

HERE'S WHAT'S NEW for members this week:

🧬 Dr. Stephanie gets (quite) candid about obesity and genetics in her SOLO episode.

💪 Dr. Stephanie and Nathalia Melo talk about women's strength training and realistic fitness goals on the podcast. You don't want to miss the after-show comments (exclusively for Premium Members!)

DON'T MISS OUT! Join other like-minded Bettys in a community where you can get exclusive access and resources.

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  • Insights from the guest discussions coupled with recommendations you can use to build habits and routines that support your goals.
  • Ask Me Anything” episodes.
  • “Dr. Stephanie SOLO” shows.
  • Action guides. Coming in 2025!
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  • Exclusive discounts on favorite brands.

Subscribe HERE to find a membership option that fits your budget.