episode #364

Tired AF? Metabolic & Mitochondrial Secrets with Dr. Casey Means


Dr. Casey Means uncovers the ancestral roots of mitochondrial health and discusses the modern-day factors contributing to illness and fatigue. Both Dr. Means and Dr. Stephanie provide invaluable insights and actionable tips for optimizing health.

“Our insatiable cravings are because we are sending mixed messages to our body with the food that we’re putting in, and if we put real, unprocessed food in, our body will respond beautifully and stop us from being hungry.”
– Dr. Casey Means

Covering topics such as nutrition, sleep, stress, and lifestyle factors, this conversation offers a wealth of knowledge for listeners at any stage of their health journey. Tune in to discover the secrets to unlocking your full health potential and embarking on a journey to self-optimization.

Episode Overview:

0:00 Intro/teaser
3:45 Unveiling Mitochondrial Health
11:58 Healthcare System and Root Cause Issues
20:35 Empowering Patients to Take Control
25:33 Modern Food, Health, and Technology
41:12 Building Meals: Components for Cellular Health
38:59 Optimizing Health Through Nutrition and Thermoneutrality
43:40 The Impact of Indoor Living on our Biology
45:03 Harnessing Cosmic Energy Through Mitochondrial Health
46:38 Incorporating Temperature Play into Daily Life
50:47 The Importance of Movement and Walking
55:33 The Influence of Artificial Light on Circadian Rhythms
58:57 Utilizing Wearables to Track Movement
1:01:50 Embracing Sunlight and Overcoming Fear
1:14:02 Fearlessness as the Ultimate Good Energy
1:19:30 Connecting with the Eternal Source of Life

Resources mentioned

Good Energy by Dr. Casey Means is a paradigm-shifting book that offers a radical new understanding of the roots of disease and highlights the importance of optimizing our metabolic health.

Trends and Disparities in Cardiometabolic Health Among U.S. Adults, 1999-2018

Steps per Day and All-Cause Mortality in Middle-aged Adults in the Coronary Artery Risk Development in Young Adults Study

The Mini Pause newsletter


Casey Means, MD is a Stanford-trained physician and co-founder of Levels, a health technology company with the mission of reversing the world’s metabolic health crisis. Her book on metabolic health, Good Energy, comes out in May 2024 with Penguin Random House. She received her BA with honors and MD from Stanford, was President of her Stanford class, and has served on Stanford faculty. She trained in Head & Neck Surgery before leaving traditional medicine to devote her life to tackling the root cause of why Americans are sick. She has been featured in The New York Times, The New Yorker, The Wall Street Journal, Forbes, Women’s Health, and more. Find out more at caseymeans.com/

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I’m Dr. Stephanie

Part geek, part magic, and all the way passionate about being a well-lived woman.

I want to throw my grandkids in the air in my 70’s. I want to be squatting even more weight than I am now, and putting my OWN luggage in the overhead bin. Sound like weird goals? For me these are just some of the little things that represent a life well-lived.

My health is MY job – I’ll be damned if I rely on luck, ‘good genes’ or a cocktail of drugs that over promise and under deliver.

The Betty Body is my first book-baby, and a collection of what I’ve learned after thousands of clinical hours, hundreds of conversations with the world’s top experts, and most importantly…

This book is an outline of what took ME from “rock-bottom health” at 38, to being my own version of a Betty in my perimenopausal mid 40’s. A woman who is physically strong, full of energy, enjoys mental clarity, great sex and a joyful family life. Is it all roses? Of course not. But I have the stamina and tools to deal with the push and pull of life so that it doesn’t turn into chronic stress.

I want this for you too. Let’s go Bettys!