episode #372

Skin Health & Sex Hormones in Perimenopause with Dr. Amy B Killen


Dive deep into the intricate world of hormone replacement therapy (HRT) with the esteemed Dr. Amy Killen, a pioneer in longevity and regenerative medicine. Join Amy as she explores the nuances of HRT, including the roles of progesterone, estrogen, and testosterone in women’s health.

“Women need to be their own advocates in healthcare settings, especially when it comes to hormone replacement therapy.” Dr. Amy B Killen

Dr. Killen shares her expertise on the optimal ages and dosages for HRT, as well as its impact on sexual health, cardiovascular health, and mental well-being. We also delve into cutting-edge skin rejuvenation therapies, from stem cell treatments to Botox and fillers, and Dr. Killen’s personal supplementation stack for maintaining youthful vitality. This episode is packed with actionable insights and expert advice to help you optimize your health and longevity.

Episode Overview:

0:00 Intro/Teaser
4:02 What is Perimenopause?
7:53 Hormonal Changes in Perimenopause
11:20 Navigating the Moving Target of Perimenopause
21:48 Estrogen’s Crucial Role in Sexual Health
25:08 Understanding Testosterone in Women
27:31 Dosing and Treatment Options for Women
34:10 Debunking Myths About Estrogen and Breast Cancer
38:41 When to Stop Hormone Replacement Therapy
41:41 Sexual Health and Longevity
47:39 Mechanism of Nitric Oxide in Sexual Health
1:00:25 Impact of Botox on the Beauty Industry
1:04:44 Skin Health and Peptides
1:07:08 Concerns and Misconceptions About Botox
1:08:38 Dr. Amy’s Own Skin Care Procedures
1:13:50 Where to find Dr. Amy Killen

Resources mentioned in the episode:

Websites: dramykillen.com, hopbox.life, and reputable.health

JoyLux Gold Plus red light therapy

Testosterone therapy in women: myths and misconceptions

Estrogen Matters book – estrogenmatters.com

Previous episode: HRT, Bioidenticals & Menopause: Benefits & Risks

Equip food collagen – equipfoods.com/better and use the code BETTER for 20% off.


Amy B. Killen is a leading longevity and regenerative physician, founder, and speaker.  She and her partner, Dr Adelson, pioneered the Full Body Stem Cell Makeover. Dr Killen is the founder and CEO of the Human Optimization Project (HOP), a longevity-focused nutritional supplement company.  She co-founded Humanaut Health, a longevity clinic franchise, and Nof1+, a health tech data aggregator empowering insights through experimentation.

We are grateful to our sponsors:


A hot flash happens when the brain sends a false signal that says you’re too hot. And now there’s a way for you to manage hot flashes in perimenopause and menopause with the Embr Wave 2. This thermoregulation device looks like a gorgeous bracelet. With the push of a button, you can cool off. Go to embrlabs.com and use code DRSTEPHANIE for 15% off.


Feeling tired and having no energy does not have to be your fate. Mitopure is a supplement and skin health line that helps improve energy at the level of the mitochondria so that you can continue to engage in the activities you love. Go to timelinenutrition.com/better and use code BETTER to get 10% off your order.


I take a shot of beam minerals before I do a cold plunge to get the full recovery benefits of all that cold. Beam is a full-spectrum liquid mineral supplement that gives you every single mineral that your body needs. You can try some by heading over to beamminerals.com/better and using the code BETTER at checkout to save 20% off your first order.

I’m Dr. Stephanie

Part geek, part magic, and all the way passionate about being a well-lived woman.

I want to throw my grandkids in the air in my 70’s. I want to be squatting even more weight than I am now, and putting my OWN luggage in the overhead bin. Sound like weird goals? For me these are just some of the little things that represent a life well-lived.

My health is MY job – I’ll be damned if I rely on luck, ‘good genes’ or a cocktail of drugs that over promise and under deliver.

The Betty Body is my first book-baby, and a collection of what I’ve learned after thousands of clinical hours, hundreds of conversations with the world’s top experts, and most importantly…

This book is an outline of what took ME from “rock-bottom health” at 38, to being my own version of a Betty in my perimenopausal mid 40’s. A woman who is physically strong, full of energy, enjoys mental clarity, great sex and a joyful family life. Is it all roses? Of course not. But I have the stamina and tools to deal with the push and pull of life so that it doesn’t turn into chronic stress.

I want this for you too. Let’s go Bettys!