episode #342

Hormone Optimization: Testosterone, HRT, Hair Loss & Obesity with Dr. Kyle Gillett, MD


In this rebroadcast of the orginal conversation from earlier this year, Dr. Kyle Gillett and Dr. Stephanie discuss hormones, focusing on the nuances of testosterone, dihydrotestosterone, and DHEA, and how these hormones transform the various stages of life.

Dr. Kyle Gillett and Dr. Stephanie embark on a deep dive into the intricate world of hormones, with a special focus on androgens. They explore the nuances of testosterone, dihydrotestosterone, and DHEA, unravelling how these hormones transform the various stages of both a man and a woman’s life.

During the conversation they touch on the critical role of sleep, discuss the complexities of PCOS, and delve into the mysteries of hair and hair loss. They also explore TRT, or testosterone replacement therapy, and the broader spectrum of hormonal replacement therapy for women.

Dr. Kyle also shares his knowledge in the realm of obesity, exploring the neurobiology and genetic foundations that contribute to this complex issue. So, get ready for a journey through the lipostat and ventromedial hypothalamus—yes, all the geeky things that Dr. Stephanie loves to dissect.

Whether you’re a seasoned clinician or someone navigating the challenges of hormonal changes, this conversation is packed with insights. Clinicians, this is your golden ticket to rounding out your understanding and gaining valuable clinical pearls for patient management. And for all you wonderful patients out there, especially those experiencing menopause and perimenopause, we’ve got you covered.


Dr. Gillett is a Board Certified Family Med, Board Certified Obesity Med who enjoys providing holistic individualized care to his patients. His practice includes preventative medicine, aesthetics, sports medicine, hormone optimization, obstetrics and infertility, integrative medicine, and precision medicine including genomics. He believes that each human is a unique creation that requires attention to their body, mind, and soul to achieve optimal health.


IG – https://www.instagram.com/kylegillettmd/
Website – https://gilletthealth.com/
Podcast – https://podcasts.apple.com/ca/podcast/the-gillett-health-podcast/id1631735999
YouTube – https://www.youtube.com/@gilletthealth6738/videos
IG – https://www.instagram.com/gilletthealth/


Gorilla Mind – https://gorillamind.com


00:00:00 Introduction
00:02:48 Welcome to Dr. Kyle Gillett and the Topic of Hormones
00:12:02 The Best Diet: Omnivorous or Plant-Based?
00:22:03 Differential Conversion of Testosterone to DHT in Various Cells
00:24:31 PCOS and Androgen Dominance
00:30:53 Optimizing DHT Levels in the Body
00:32:04 Creatine and Its Impact on DHT Levels
00:33:45 Extending Fertility in Women and the Role of HRT
00:36:58 The Importance of Maintaining a High-Performing Body
00:42:35 L-Carnitine: An Option for Plant-Based Diets
00:46:39 Boron and Its Role in Hormone Optimization
00:50:06 Half-life of SHBG and Its Regulation
00:53:26 Hair Loss and the Different Types of Hair Loss Explained
01:02:17 Practices for Improving Sleep and Hormone Optimization
01:06:21 The Connection Between Sleep, Menopause, and Estrogen Reduction
01:07:59 The Complexity of Obesity and Calorie Balance
01:13:05 Importance of Maintaining Lean Body Mass During Weight Loss
01:16:17 Strategies to Circumvent Feedback Mechanisms for Weight Loss
01:20:43 Strategies to Slow Down Eating and Practice Intuitive Eating
01:29:14 Leptin and Its Role in Satiety and Fat Mass
01:35:31 Why Don’t All of Us Become Obese? Genetic Factors
01:38:33 Testosterone, Dopamine, and Palatability of Foods



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I’m Dr. Stephanie

Part geek, part magic, and all the way passionate about being a well-lived woman.

I want to throw my grandkids in the air in my 70’s. I want to be squatting even more weight than I am now, and putting my OWN luggage in the overhead bin. Sound like weird goals? For me these are just some of the little things that represent a life well-lived.

My health is MY job – I’ll be damned if I rely on luck, ‘good genes’ or a cocktail of drugs that over promise and under deliver.

The Betty Body is my first book-baby, and a collection of what I’ve learned after thousands of clinical hours, hundreds of conversations with the world’s top experts, and most importantly…

This book is an outline of what took ME from “rock-bottom health” at 38, to being my own version of a Betty in my perimenopausal mid 40’s. A woman who is physically strong, full of energy, enjoys mental clarity, great sex and a joyful family life. Is it all roses? Of course not. But I have the stamina and tools to deal with the push and pull of life so that it doesn’t turn into chronic stress.

I want this for you too. Let’s go Bettys!